Abstract: The fatigue properties of aluminum foam sandwich panels prepared by bonding method were studied by three-point bending test. The effects of different panel thickness and density of core layer on the bending fatigue life and failure mode of the sandwich panel are analyzed. The results show that the average life of foamed aluminum sandwich panel is determined by the thickness of the panel and the density of the core layer. The fatigue life increases with the increase of the thickness of the panel and the density of the core layer. The main failure mode of bending fatigue of composite structure is shear failure of core layer. The results can provide reference for the practical engineering design and application of aluminum foam sandwich panel.