Abstract: TB3 titanium alloy bar with coarse crystal structure was subjected to heat treatment. The microstructure evolution of the titanium alloy bar after different deformation rolling and solid solution heat treatment were studied, and an effective method to improve the microstructure uniformity of titanium alloy bar was put forward. The results show that, the longitudinal coarse crystal structure of TB3 titanium alloy bar is banded during rolling. The larger the deformation is, the thinner the coarse grain structure is. After forging, when the size of coarse grain is less than 200 μm and the rolling deformation is 95%, the phenomenon of coarse grain can be eliminated after solid solution heat treatment.