Abstract: In order to solve the difficult forming problem of a large titanium alloy framework with complex shape and thin wall, the forming process route of the framework was analyzed. The reasonable sectional casting was designed, proper process reinforcement bars and welding positioning stop were arranged, the optimal welding sequence was selected, and five-axis machining was carried out after welding. The results show that the manufacturing framework meets the technical requirements, and the manufacturing cost is much lower than that of traditional molding method. This can provide reference for the processing and production of similar parts.