Abstract: There are many factors affecting resistance spot welding of GH4169 superalloy. Firstly, a single-point resistance spot welding simulation model of the clamp composed of band and ring with different thickness was established,and the effects of welding current, energizing time and electrode pressure on the nugget size and temperature field during spot welding were analyzed. Then, a multi-point resistance spot welding model was established, and the influence of the number of welding spots and the position of welding spots on the deformation and stress of the workpiece was studied. The results show that the welding nugget size and the penetration rate both increase with the welding current and welding time increasing; while the welding nugget size and welding temperature both decreases with the electrode pressure increasing. The total deformation and equivalent stress increase with the increase of the number of solder joints and decrease with the increase of the distance of solder joints. When the number of solder joints is 2, and the distance between the two welding spots is 35 mm, the welding deformation and the minimum welding stress of the multi-point welding are minimum.