Abstract: The Gleeble-3500 thermal simulation testing machine was used to perform compression deformation tests of the TC4 titanium alloy at different strain rates and deformation temperature of 900-1050℃in single-time and multi-time compression.The results show that the flow stress increases with the increase of deformation rate and decreases with the increase of temperature during single-time compression.A significant stress change is observed between the deformation temperature of 900℃and 950℃, which is related to the Welshmannesian microstructure transformation during 900℃and 950℃deformation.At the same time, when the temperature is 900℃and 950℃, the original microstructure is squashed and crushed.When the temperature is higher than 950℃, Widmanstatten structure is easy to form under large deformation.After multi-time deformation at 900℃, the lamellar structure morphology characteristics are obtained.However, when the deformation temperature is higher than 950℃, the Widmannian microstructure is formed, which will affect the mechanical properties of the material.Therefore, in order to improve the plastic deformation ability of the alloy, the deformation temperature should be controlled at 900℃to avoid the formation of Widmanstatten structure.