Abstract: High-power laser additive manufacturing TA15 titanium alloy can not only break through the limitation of traditional material reduction process, but also effectively improve the utilization rate of raw materials and processing efficiency. The effects of different solution temperatures on the phase composition, microstructure and anisotropy of mechanical properties of TA15 fabricated by high power additive were studied. The results show that the microstructure parallel to the direction of adding materials is mainly columnar crystals grown epitaxially, while the microstructure perpendicular to the direction of adding materials is equiaxed crystals. With the decrease of solution temperature, the sizes of columnar crystals and equiaxed crystals decrease obviously. It has higher tensile strength (1017.8 MPa in transverse direction, 991.9 MPa in longitudinal direction) and yield strength (929.9 MPa in transverse direction, 893.1 MPa in longitudinal direction) under the heat treatment condition of 850 ℃/2 h/air cooling+650 ℃/3 h/air cooling. Under the heat treatment condition of 950 ℃/2 h/air cooling+650 ℃/3 h/air cooling, it has better elongation(16.7% in transverse direction, 17.2% in longitudinal direction) and shrinkage (32.7% in transverse direction, 43.7% in longitudinal direction). With the increase of solution temperature, the anisotropy of tensile properties of the TA15 decreases.