Abstract: Among the metal degradable bone implant materials, zinc has good biocompatibility and corrosion resistance, making it become potential bone implant material.Spark plasma sintering was used to prepare Zn-xCu (x=0, 3, 6, 9wt%)alloy material, and its microstructure, mechanical properties, corrosion degradation performance and cytotoxicity were studied.The results indicate that the structure of the alloy prepared by spark plasma sintering is dense, and the structure is composed of Zn phase and CuZn₅ phase.Compared with pure zinc, the hardness and compressive strength of the alloy significantly improve with the addition of copper alloy elements, Zn-6Cu has the best mechanical properties, with compressive strength of 238 MPa and hardness of 73 HV.In the alloys, CuZn₅ phase is used as cathode and Zn matrix is used as anode to form galvanic cell, which can accelerate the corrosion rate of the alloy, and the corrosion rate of Zn-9Cu is highest, reaching 0.061 mm/a.At 50%and 25%extract concentration, the alloys show good biocompatibility.