Abstract: The stress-strain hybrid control(hybrid-controlled creep-fatigue interaction, HCFI)test method was adopted to carry out the creep-fatigue tests of GH4169 alloy under different strain amplitude, dwell stress level and dwell time at 650℃, and its creep deformation behavior and creep-fatigue failure evolution characteristics was studied. The results show that GH4169 alloy produce creep deformation continuously during the stress dwell period of HCFI loading. The total creep generated in each cycle increases with the increase of cycle, presenting three stages evolution trend. The creep strain during the stress dwell period of HCFI loading is the main feature which is different from the stress relaxation of the traditional strain control(SCFI), the loading method can also control the proportion of creep and fatigue damage in the process of creep-fatigue failure of materials and overcome the problem of creep damage saturation in traditional tests.