Abstract: In order to explore a new method of lightening machine tool columns, a metal/CFRP hybrid column was designed based on a machine tool column. The column structure with inner circle and outer side was designed and its topology was optimized. Combined with spider web structure, it was bionic designed and its structure size was optimized. CFRP materials were laid inside bionic columns to form metal/CFRP hybrid columns. Seven CFRP laying angle schemes were designed, and the influence of laying angle and thickness on the performance of hybrid columns was studied. The static and dynamic performance analysis of the prototype column and the metal/CFRP hybrid column shows that the weight of the metal/CFRP hybrid column is reduced by 38.7% compared with the prototype column when the CFRP ply angle is 45° and the ply thickness is 32 mm, and the static and dynamic performance is improved.