Abstract: Porous materials can not only reduce the material consumption, but also reduce the elastic modulus of material, so that it can match the natural human bone elastic modulus.The study of porous Ti6Al4V is particularly important in the biomedical field because of its good biocompatibility.The mechanical property of hollow cube, G7 and central cubic structures with similar porosity were studied.The apparent morphology and microstructure of SLM fabrication were analyzed by scanning electron microscopy and metallographic experiments.Secondly, through the compression experiment and the Abaqus finite element analysis method, the comparison of the stress-strain curve was obtained by the two ways, the simulation can better predict the maximum compressive strength of porous material.The practical experiments of the three causes of failure forms corresponding cell structure is explained by equivalent stress and equivalent plastic strain nephogram