Abstract: In pipelines with multiple corrosion defects, there may be interactions between any adjacent corrosion defects,and the interactions between corrosion defects will further reduce the failure pressure of the pipeline. By comparing the failure pressure calculated by standard specifications with that calaclated by finite element analysis, the finite element method has higher accuracy in calculating the failure pressure between multiple corrosion defects. However, the finite element method is cumbersome and computationally intensive. This article proposed a new empirical model for pipeline failure pressure considering the interaction between multiple corrosion defects. Firstly, a nonlinear finite element simulation method was used to calculate the situation of different multiple corrosion defects; secondly, a detailed analysis was conducted for the influence of dimensionless parameters on the failure pressure of pipelines; finally, the coupling forms between multiple parameters in the failure pressure formula were discussed in detail. By comparing with engineering case data, the new empirical model for calculating failure pressure has a certain degree of accuracy and convenience. In summary, the empirical model of failure pressure for corrosion defect pipelines has a wide range of applications.