Abstract: In order to investigate the laser butt welding process of BS960E high strength steel, CHW-90C high-strength steel wire was selected as filler material, and the microstructure morphology and mechanical properties of the welded joints were systematically analyzed. By adjusting the parameters such as laser power, wire feeding speed, welding speed and heat input, the influence on the welded joint was studied, and the response surface method was used to optimize the process parameters. The results show that the laser butt welding welded joints of BS960E high strength steel mainly contain M-A group elements and bainite in the weld zone, and martensite and austenite in the heat-affected zone; the hardness of the welded joints in the center and the heat-affected zone reaches more than 380 HV, the hardness of the weld zone is higher than that of the base material by about 19%, and the hardness of the softened zone is about 280 HV, and the tensile strength reaches more than 1000 MPa, and the tensile property exceeds that of the base material. Tensile properties beyond the base material; the use of response surface optimization of laser filler welding laser power, welding speed and wire feeding speed process parameters, the best process parameters with the welding speed of 1.8 m/min, laser power of 2400 W, wire feeding speed of 1.2 m/min, the production practice has confirmed that the weld quality under the combination of the parameters is excellent.