Abstract: Ti52/TC16 dissimilar titanium alloy tube joints were prepared by continuous drive friction welding with different friction pressures. The macroscopic morphology, tensile properties and fracture morphology of the welded joints were analyzed, and the joint with better performance was selected, the hardness distribution and microstructure characteristics of the connection interface area were further studied. The results show that when the friction pressure is 2.4 MPa, the thickness of the weld flash is appropriate, the welding affected area of the joint is narrow, the grain structure is fine, and the tensile strength is equal to that of the TC16 base material. Significant hardening occurs in the weld zone, and the hardness value gradually transitions to the level of the base metal as it moves away from the weld. The impact toughness of the welded joint reaches 74% of that of the TC16 base material, and the comprehensive mechanical properties of the joint are good. Flow and element diffusion occur at the interface of the base materials on both sides. There is a composition transition zone of approximately 42 μm and a uniform mixing zone of about 30 μm at the welding interface. The weld zone is mainly composed of recrystallized β phase grains, with interwoven and distributed lamellar α phase and acicular martensite α' phase. There are also local grain boundary α phases. The microstructure at the Ti52 side is finer and more uniform. As it approaches the interface, the solid solution degree of the primary α phase increases, and the α/β phase interface becomes blurred. At the TC16 side, the primary α phase of TMAZ elongates along the direction parallel to the interface, and at the Ti52 side, there is a relatively continuous metastable β phase at the edge of the primary α phase of HAZ.