Abstract: To investigate the relationship between process parameters and the morphology, microstructure of laser cladded Ni60 nickel-based alloy on the surface of a precision forging machine chuck sleeve, a three-factor four-level orthogonal experiment was designed. The effects of laser power, scanning speed, and powder feed rate on the geometric characteristics of the cladded layer on 45 steel substrate were systematically studied. Range analysis was employed to identify the dominant factors influencing crack formation in the cladded layer. With the cladding height and microhardness as comprehensive evaluation indicators, the process parameters were optimized. The results show that the highest comprehensive quality score of the cladded layer is achieved under the following optimal parameters: laser power of 1800 W, scanning speed of 3 mm/s, and powder feed rate of 0.3 r/min. Microstructural examination of the coating prepared under the optimal conditions reveals that the coating is well bonded with the substrate, the microstructure is dense, and the microstructure primarily consists of primary dendrites, secondary dendrites and fine equiaxial cryital grains.